PE-22-28 is a synthetic, truncated peptide derivative of spadin engineered as a high-affinity antagonist of the TASK-3 (K2P9.1) two-pore domain potassium channel (IC50 ≈ 2.5 nM). By selectively blocking hyperpolarizing potassium efflux in hippocampal neurons, PE-22-28 enhances central synaptic transmission, stimulates dentate gyrus neurogenesis, and upregulates brain-derived neurotrophic factor (BDNF) expression.
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PE-22-28 is a synthetic, truncated derivative of the endogenous peptide spadin (a sorting receptor sorLA-derived peptide). Engineered to isolate the minimal pharmacophore required for potassium channel inhibition, it acts as a potent, highly selective antagonist of the TASK-3 (K2P9.1) two-pore domain potassium channel, displaying nanomolar affinity (IC50 ≈ 2.5 nM) that significantly surpasses parent spadin sequences.
By blocking background hyperpolarizing potassium currents in hippocampal neural networks, PE-22-28 facilitates neuronal membrane depolarization, driving rapid neurotrophic signaling, synaptogenesis, and adult dentate gyrus neurogenesis.
Batch-verified for high analytical purity at Modern Aminos, PE-22-28 is offered as a 10MG lyophilized reference powder sealed in a 2R glass vial. Laboratories investigating two-pore domain potassium channel biophysics, rapid neuro-plasticity cascades, and neurotrophic factor upregulation evaluated alongside complementary neuro-regulatory reference standards available on the site, such as Semax, NSI-189 Phosphate, Selank, and Pinealon.
| Compound Name | PE-22-28 (Spadin Analog) |
|---|---|
| Quantity / Formats Offered | 10MG Lyophilized Powder in 2R Glass Vial |
| Peptide Sequence | Gly-Val-Sery-Trp-Gly-Leu-Arg (Truncated Spadin Sequence) |
| Synonyms / Alt Names | PE 22-28, Truncated Spadin Analog, TASK-3 Inhibitor PE-22-28 |
| CAS Number | 1638338-30-1 |
| Chemical Formula | C32H52N10O10S |
| Molecular Weight | 768.89 g/mol |
| IUPAC Name | L-glycyl-L-valyl-L-seryl-L-tryptophyl-glycyl-L-leucyl-L-arginine |
| InChIKey | Protected Peptide Sequence Matrix |
| SMILES Code | CC(C)C(C(=O)NC(CO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)O)N |
The biochemical pathways and cellular targets:
When evaluating research efficacy and published scientific literature:
To evaluate ion channel targets, neurotrophic signaling, and neuroplasticity cascades, researchers compare PE-22-28 against alternative reference standards available at Modern Aminos:
| Compound / Reference | Primary Receptor / Channel Target | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| PE-22-28 | TASK-3 (K2P9.1) Two-Pore Potassium Channel Antagonist | Blocks background leak K+ currents to depolarize neurons, driving BDNF expression and dentate gyrus neurogenesis | Focuses on potassium channel biophysics, rapid neuroplasticity, hippocampal neurogenesis, and spadin pharmacophore optimization |
| Semax | ACTH(4-10) Derived Synthetic Heptapeptide | Upregulates hippocampal BDNF and NGF expression while modulating central dopaminergic and cholinergic neurotransmission | Focuses on rapid cognitive stimulation, executive function, memory consolidation, and acute neuroprotective vascular signaling |
| NSI-189 Phosphate | Benzylpiperazine Aminopyridine Derivative | Stimulates neurogenesis and synaptic expansion specifically in the hippocampal dentate gyrus subgranular zone | Focuses on structural hippocampal volume recovery, dendritic arborization, and cell-line proliferation assays |
| Selank | Tuftsin-Derived Synthetic Heptapeptide | Stabilizes central enkephalins, modulates GABAergic signaling, and increases BDNF expression | Focuses on non-sedating emotional stress buffering, immunomodulation, and central neuropeptidative homeostasis |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct molecular weight (768.89 g/mol), exact peptide sequence fidelity, and complete absence of heavy metals or synthesis impurities.
PE-22-28 is a synthetic, truncated 7-amino-acid peptide derived from spadin (a sorLA-derived endogenous peptide). It isolates the active binding pharmacophore required to inhibit TASK-3 potassium channels with higher affinity than full-length spadin.
TASK-3 (K2P9.1) channels mediate background potassium leak currents that keep neurons hyperpolarized. By blocking TASK-3, it allows slight membrane depolarization, triggering calcium-dependent CREB phosphorylation and driving BDNF synthesis, which stimulates neural stem cell neurogenesis.
Semax is an ACTH(4-10) analogue that upregulates BDNF and NGF via melanocortinergic and monoaminergic receptor modulation. It acts through a distinct biophysical mechanism, directly antagonizing TASK-3 potassium leak channels to induce membrane depolarization and BDNF release.
Modern Aminos supplies PE-22-28 as a 10MG lyophilized reference powder cake packaged in a 2R glass vial fitted with a multi-entry rubber stopper and flip-off seal to preserve solid-state peptide stability.
In neuronal cell cultures, PE-22-28-mediated TASK-3 blockade increases extracellular BDNF levels, promoting dendritic spine density, synaptotagmin expression, and functional synaptic connection formation in hippocampal networks.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular mass (768.89 g/mol) and primary sequence identity prior to batch release.
Unopened lyophilized vials should be stored frozen at -20°C for long-term preservation. Protect from direct light exposure, elevated temperatures, and atmospheric moisture to maintain solid-state peptide stability.
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