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Product | BPC-157 (Pentadecapeptide)

BPC-157 (Pentadecapeptide)

BPC-157 acetate is a lyophilized pentadecapeptide research material commonly evaluated in laboratory studies involving peptide characterization, molecular interactions, and biological signaling pathways.  Please visit the product page for BPC-157 Arginate (Pentadeca Arginate) to view more details about our 500mcg dry-fill capsules.

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What is BPC-157 (Pentadecapeptide)?

BPC-157 (known chemically as Body Protection Compound-157, PL 14736, PL-10, or BeMatrix-157) is a synthetic 15-amino-acid pentadecapeptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a biologically active fragment of human gastric cytoprotective protein. Structurally stabilized to resist proteolytic enzymatic degradation, BPC-157 serves as a benchmark reference peptide in extracellular matrix (ECM) research.

Operating across multiple cell-signaling pathways, BPC-157 (Pentadecapeptide) promotes microvascular endothelial cell proliferation by upregulating vascular endothelial growth factor receptor 2 (VEGFR2) and internalizing VEGFR2/Akt signaling. BPC-157 accelerates tenocyte and fibroblast migration through the focal adhesion kinase (FAK) and paxillin phosphorylation cascade, facilitating organized type I collagen matrix deposition and tissue architecture restoration.

Batch-verified for high analytical purity at Modern Aminos, BPC-157 is supplied in 5MG and 10MG formats in 2R glass vials. Researchers evaluating soft tissue re-vascularization, tendon/ligament bioenergetics, and angiogenesis utilize BPC-157 alongside complementary reference standards, such as Thymosin Beta-4, KPV, and GLOW.

Chemical and Molecular Data

Compound Name BPC-157 (Body Protection Compound-157)
Available Formats Offered • 5MG Lyophilized Dry Powder in 2R Glass Vial
• 10MG Lyophilized Dry Powder in 2R Glass Vial
Chemical Structure Synthetic 15-Amino-Acid Gastric-Derived Pentadecapeptide
Peptide Sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Synonyms / Alt Names BPC-157, PL 14736, PL-10, Pentadecapeptide BPC 157, BeMatrix-157
CAS Number 137525-51-0
Chemical Formula C62H98N16O22
Molecular Weight 1419.53 g/mol
IUPAC Name L-valine, L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-
InChIKey InChIKey=OIRCOZZYDOEUBO-UHFFFAOYSA-N
SMILES Code Protected Peptide Sequence Matrix

What are the Mechanisms of Action?

The biochemical pathways and cellular targets of BPC-157 (Pentadecapeptide) in laboratory research include:

  • VEGFR2 Upregulation & Angiogenic Sprouting: BPC-157 increases the expression and activation of vascular endothelial growth factor receptor 2 (VEGFR2) on endothelial cells. This activates downstream Akt and eNOS phosphorylation cascades, accelerating endothelial cell proliferation, migration, and capillary tube formation.
  • FAK-Paxillin Axis & Fibroblast/Tenocyte Outgrowth: In tendon and ligament explant cultures, BPC-157 (Pentadecapeptide) stimulates the phosphorylation of focal adhesion kinase (FAK) and paxillin. This coordinates cytoskeletal rearrangement, promoting tenocyte migration and facilitating organized type I collagen fibrillogenesis.
  • Nitric Oxide (NO) System Regulation: BPC-157 stabilizes the balance between endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS), maintaining basal microvascular perfusion and preventing excessive, destructive inflammatory NO surges under ischemic conditions.
  • Egr-1 & Growth Hormone Receptor (GHR) Expression: BPC-157 upregulates early growth response gene 1 (egr-1), a master transcription factor controlling cellular proliferation, while increasing GH receptor density on fibroblasts to enhance cellular responsiveness.

What do Preclinical & Academic Studies Show for BPC-157?

When evaluating published scientific literature and bioenergetic monographs for BPC-157:

  • Tendon Biology & Fibroblast Signaling (PubMed): Landmark connective tissue studies cataloged on PubMed (PMID: 21030672) confirm that BPC-157 promotes tendon outgrowth, upregulates GH receptor expression in tendon fibroblasts, and accelerates transected tendon revascularization.
  • Angiogenesis & Cytoprotective Remodeling (PMC): Comprehensive biomedical reviews archived in PMC (PMC6271067) document BPC-157’s capacity to induce VEGFR2-mediated vascular network expansion, accelerate granulation tissue formation, and protect gastrointestinal mucosal barriers.
  • Chemical Profiling & Molecular Verification (PubChem): Official structural characterization maintained on PubChem verifies the molecular mass (1419.53 g/mol), 15-amino-acid peptide sequence, and HPLC mass spectrometry profile of CAS 137525-51-0.

How does BPC-157 (Pentadecapeptide) compare across formats and related compounds?

To evaluate peptide mechanisms, structural targets, and formulation synergy, researchers compare BPC-157 against alternative reference standards available at Modern Aminos:

BPC-157 (5MG vs. 10MG Vials) & Multi-Peptide Blends

  • 5MG Lyophilized 2R Glass Vial: Tailored for standard benchtop microplate assays, dose-response curve generation, and short-term cell culture modeling requiring fresh, periodic batch preparation.
  • 10MG Lyophilized 2R Glass Vial: High-density format ideal for extended epithelial explant studies, high-throughput screening runs, and multi-well connective assay matrices.
  • BPC-157 + Thymosin Beta-4: Combines BPC-157’s VEGFR2-mediated tubulogenesis and fibroblast proliferation mechanisms with Thymosin Beta-4’s G-actin-mediated cell motility, creating a synergistic dual-action matrix for structural connective tissue and extracellular matrix (ECM) research..
Compound / Reference Chemical Structure & Class Core Mechanism of Action Primary Research Focus
BPC-157 (Pentadecapeptide) 15-Amino-Acid Gastric Pentadecapeptide Upregulates VEGFR2 angiogenesis, stimulates FAK/paxillin tenocyte migration, and modulates NO Fibroblast matrix remodeling, microvascular network formation, localized structural protein deposition, and mucosal barrier resilience.
Thymosin Beta-4 Thymosin β4 Active Domain Fragment Sequestration of monomeric G-actin to drive rapid cell motility, migration, and tissue re-epithelialization Cytoskeletal remodeling, actin-mediated cell motility, and muscle fiber re-vascularization
Copper Tripeptdie-1 Copper-Chelated Tripeptide (Gly-His-Lys) Stimulates pro-collagen, elastin, and decorin gene transcription; activates SOD1 antioxidant defense Fibroblast modulation, epithelial barrier homeostasis, fibrotic pathway attenuation, and broad-spectrum extracellular matrix (ECM) synthesis.
BPC-157 + Thymosin Beta-4 BPC-157 + Thymosin Beta-4 Blend Coupled VEGFR2 angiogenesis (BPC) with G-actin cytoskeletal migration (TB-500) Synergistic multi-pathway connective tissue remodeling, combining endothelial tubulogenesis with rapid cellular migration.

Frequently Asked Questions (FAQs)

1. Is Modern Aminos a reliable place to buy BPC-157?

Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch of BPC-157 (across both 5MG and 10MG formats) undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact 15-amino-acid sequence fidelity, correct molecular weight (1419.53 g/mol), and complete absence of heavy metals or synthesis impurities.

2. What is BPC-157 peptide and how is it derived?

BPC-157 is a synthetic 15-amino-acid pentadecapeptide derived from the sequence of human gastric juice cytoprotective protein. It is engineered to maintain high structural stability in enzymatic and acidic environments.

3. How does BPC-157 promote angiogenesis and microvascular endothelial growth?

BPC-157 increases VEGFR2 expression and activates Akt/eNOS signaling pathways, stimulating endothelial cell proliferation, migration, and the rapid formation of organized microvascular capillary networks.

4. What vial formats of BPC-157 are available from Modern Aminos?

Modern Aminos supplies analytical-grade BPC-157 in two solid formats: 5MG Lyophilized Dry Powder in a 2R glass vial and 10MG Lyophilized Dry Powder in a 2R glass vial, catering to both low-volume microplate assays and larger multi-well screening protocols.

5. What role does BPC-157 play in tendon and ligament connective tissue research?

BPC-157 activates the FAK/paxillin pathway in fibroblasts and tenocytes, accelerating cell migration toward injured matrix zones and upregulating Growth Hormone Receptor (GHR) expression to promote organized type I collagen deposition.

6. How does BPC-157 compare to TB-500 in tissue remodeling assays?

BPC-157 operates primarily via VEGFR2 angiogenesis and FAK/paxillin tenocyte outgrowth. TB-500 functions through G-actin monomer sequestration to drive rapid cytoskeletal motility and wound re-epithelialization.

7. How does Modern Aminos verify the chemical purity and mass identity of BPC-157?

Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (1419.53 g/mol) and sequence structure prior to batch release.

8. What are the recommended storage parameters for lyophilized BPC-157 2R glass vials?

Lyophilized BPC-157 glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct light, heat exposure, and atmospheric moisture to maintain solid-state peptide stability.

DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.

Why Choose Modern Aminos?

Modern Aminos is the best place to buy peptides online. We are a trusted Research Chemicals vendor with formulations that meet industry standards and comply with quality regulations in Europe, USA, and Canada to ensure product safety and efficiency.

Our products are routinely and rigorously tested for purity, with COAs verifiable through third-party laboratory testing services.

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DISCLAIMERS

The products available for purchase from Modern Aminos are intended solely for research and laboratory use. These compounds are not designed for human consumption or the diagnosis, treatment, cure, or prevention of any disease or condition.

All customers are presumed to be research professionals who understand that any compounds purchased from Modern Aminos will be handled in accordance with safety protocols mandated by their respective regulatory agencies.

Modern Aminos does not endorse the use of these products in a non-clinical setting or any other non-laboratory-based operations. By purchasing any of these compounds, you acknowledge that you will use them for legitimate research purposes only.

Modern Aminos shall not be held liable for injuries or damages resulting from the handling or use of our products. If you do not agree with these conditions, we advise  you not to proceed with the purchase of any research compounds from our company.

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