BPC-157 Arginate (Pentadeca Arginate)

Product | BPC-157 Arginate (Pentadeca Arginate)

BPC-157 Arginate (Pentadeca Arginate)

BPC-157 Arginate (Body Protection Compound-157 L-Arginine Salt) is a highly stable salt formulation of the synthetic pentadecapeptide Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Engineered to enhance thermal and acidic stability over standard acetate salts, BPC-157 Arginate activates VEGFR2 and focal adhesion kinase (FAK) signaling, upregulates endothelial nitric oxide synthase (eNOS), and promotes fibroblast cell migration during extracellular matrix repair.

€80.00

What is BPC-157 Arginate (Pentadeca Arginate)?

BPC-157 Arginate (known chemically as Body Protection Compound-157 L-Arginine Salt or Bepecin Arginate) is an advanced salt formulation of the 15-amino-acid synthetic peptide derived from human gastric juice protein sequences. By pairing the core pentadecapeptide sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) with an L-arginine counter-ion complex, the L-Arginate version exhibits superior structural resistance against acidic pH degradation and enzymatic breakdown compared to conventional acetate peptide salts. Operating primarily through vascular endothelial growth factor receptor 2 (VEGFR2) activation and focal adhesion kinase (FAK) phosphorylation, Pentadeca Arginate promotes capillary tube formation, fibroblast proliferation, and extracellular matrix assembly. Batch-verified for high analytical purity at Modern Aminos, BPC-157 Arginate is supplied in a pre-measured 500mcg dry-fill solid oral capsule format (60 units per bottle). Laboratories investigating cellular cytoprotection, nitric oxide pathway kinetics, and tendon-to-bone junction repair evaluated alongside related reference standards available on the site, such as BPC-157 Acetate, TB-500, KPV, and GHK-Cu.

Chemical and Molecular Data

Compound Name	BPC-157 Arginate (Pentadeca Arginate)
Quantity / Formats Offered	500mcg Dry-Fill Capsules (60 Units per Bottle)
Peptide Sequence	`Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val`
Synonyms / Alt Names	BPC-157 L-Arginine Salt, Bepecin Arginate, BPC 157 Salt, PL 14736 Arginate
CAS Number	137525-51-0 (Parent Pentadecapeptide)
Chemical Formula	C₆₂H₉₈N₁₆O₂₂ · C₆H₁₄N₄O₂
Molecular Weight	1573.65 g/mol (Parent) \| 1747.85 g/mol (Arginate Salt Complex)
IUPAC Name	L-α-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-alanylglycyl-L-leucyl-L-valine; (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
InChIKey	Protected Synthetic Peptide-Salt Complex
SMILES Code	`Protected Peptide Sequence Matrix`

What are the Mechanisms of Action?

The biochemical pathways and cellular targets:

VEGFR2 Activation & Angiogenic Signaling: Triggers rapid phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2). This internalizes receptor complexes and activates the Src-FAK-paxillin signaling pathway, promoting endothelial cell sprouting and lumen formation in cell culture models.
Endothelial Nitric Oxide Synthase (eNOS) Upregulation: Stimulates eNOS activity, increasing local nitric oxide (NO) generation. Enhanced NO signaling modulates microvascular tone, dampens leukocyte adhesion, and protects endothelial wall integrity under oxidative strain.
Enhanced Acidic & Enzymatic Stability: The L-arginine counter-ion protects the pentadecapeptide backbone against cleavage by gastric pepsin and proteases. In simulated peptic fluid assays, it maintains over 90% structural integrity after 5 hours, whereas standard BPC-157 acetate degrades rapidly within 15 minutes.

What do Preclinical & Academic Studies Show?

When evaluating research efficacy and published scientific literature:

Gastric Stability & Angiogenic Kinetics (PubMed): Landmark biomedical studies cataloged on PubMed (PMID: 21030672) confirm that the L-arginine salt complex dramatically enhances peptide survival in simulated gastric environments, maintaining full biological activity and VEGFR2 signaling.
Cytoprotection & Tissue Remodeling Networks (PMC): Comprehensive reviews archived in PMC (PMC8540866) detail BPC-157’s organo-protective properties, documenting accelerated collagen type I deposition and tendon fibroblast migration in extracellular matrix assays.
Chemical Profiling & Identification (PubChem): Official structural characterization maintained on PubChem verifies the molecular mass (1419.56 g/mol parent), primary sequence fidelity, and HPLC mass spectrometry profiles of CAS 137525-51-0.

How does BPC-157 Arginate compare to other compounds?

To evaluate peptide stability, signaling pathways, and extracellular matrix kinetics, researchers compare it against alternative reference standards available at Modern Aminos:

Compound / Reference	Chemical Structure & Form	Core Mechanism of Action	Research Focus & Profile
BPC-157 Arginate	Pentadeca Arginine Salt Complex	Activates VEGFR2 and eNOS while providing high resistance to acidic/peptic enzymatic breakdown	Focuses on enhanced chemical stability, gastric cytoprotection, tendon/ligament matrix repair, and microvascular sprouting
BPC-157 Acetate	Standard Pentadecapeptide Acetate Salt	Triggers VEGFR2 phosphorylation and focal adhesion kinase (FAK) cell migration pathways	Standard baseline reference compound evaluated in cellular tissue repair and angiogenic culture models
TB-500 (Thymosin Beta-4 Fragment)	Synthetic Acetylated Peptide (Ac-SDKP)	Sequestrates G-actin monomers to promote actin polymerization, cell motility, and tissue regeneration	Focuses on actin cytoskeleton dynamics, cell migration across damaged tissue matrices, and cardiac repair pathways
KPV	α-MSH C-Terminal Tripeptide (Lys-Pro-Val)	Inhibits nuclear factor kappa B (NF-κB) nuclear translocation to block pro-inflammatory cytokines	Focuses strictly on targeted cellular anti-inflammation, mucosal barrier stabilization, and acute cytokine dampening

Frequently Asked Questions (FAQs)

1. Is Modern Aminos a reliable place to buy Pentadeca Arginate?

Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct arginine salt stoichiometry, exact pentadecapeptide sequence identity, and complete absence of heavy metals or synthesis impurities.

2. What is the molecular sequence and salt composition of BPC-157 Arginate?

Pentadeca Arginate consists of the 15-amino-acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val complexed with an L-arginine counter-ion salt (C₆₂H₉₈N₁₆O₂₂ · C₆H₁₄N₄O₂).

3. How does BPC-157 Arginate differ from standard BPC-157 Acetate?

While both compounds share the identical 15-amino-acid sequence, Pentadeca Arginate version utilizes an L-arginine salt binding complex that protects the peptide from enzymatic and acidic degradation. In simulated gastric fluid assays, this allows the compound to remain intact significantly longer than BPC-157 acetate.

4. What role does this compound have in VEGFR2 activation and angiogenesis?

In endothelial cell assays, Pentadeca Arginate binds and phosphorylates VEGFR2 receptors, initiating Src-FAK signaling cascades that promote capillary sprouting, cell migration, and structural vessel assembly in damaged tissue models.

5. What are the advantages of Modern Aminos’ 500mcg dry-fill capsule format?

Modern Aminos provides Pentadeca Arginate in pre-measured 500mcg dry-fill solid capsules (60 units per bottle). This format provides precise solid-state unit-mass control for analytical benchtop weighing and long-term shelf stability without environmental exposure.

6. How does BPC-157 Arginate compare to TB-500 in tissue remodeling assays?

Research suggests Pentadeca Arginate operates primarily through VEGFR2 activation, eNOS upregulation, and focal adhesion kinase (FAK) signaling. TB-500 operates by sequestering G-actin monomers to regulate actin polymerization, cell motility, and cytoskeletal structure during tissue repair.

7. How does this compound modulate endothelial nitric oxide synthase (eNOS)?

Research shows an upregulation in eNOS enzyme expression, driving steady-state nitric oxide (NO) synthesis. Pentadeca Arginate maintains endothelial microvascular tone, dampens leukocyte adhesion, and protects cellular integrity during oxidative or inflammatory stress.

8. What are the recommended storage parameters for capsules?

Bottles containing dry-fill BPC-157 Arginate capsules should be stored tightly sealed in a cool, dry environment (15°C to 25°C) away from direct sunlight, heat, and moisture. Stored under controlled laboratory conditions, BPC-157 Arginate capsules maintain complete chemical stability throughout their designated shelf life.

DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.

Capsule products are not intended for time-release and are for transport only.

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The products available for purchase from Modern Aminos are intended solely for research and laboratory use. These compounds are not designed for human consumption or the diagnosis, treatment, cure, or prevention of any disease or condition.

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