Nooglutyl (N-(5-hydroxynicotinoyl)-L-glutamic acid) is a potent synthetic nootropic and neuroprotective agent derived from glutamic acid and 5-hydroxynicotinic acid. Engineered to modulate central glutamatergic signaling, Nooglutyl acts as a positive modulator of AMPA and NMDA receptor complexes, enhancing hippocampal synaptic plasticity, long-term potentiation (LTP), and anti-hypoxic cellular resilience.
Log in to view prices
Want to be notified when this product is back in stock?
Nooglutyl (known chemically as N-(5-hydroxynicotinoyl)-L-glutamic acid or ONK-10) is a novel synthetic nootropic compound developed through the structural conjugation of L-glutamic acid with 5-hydroxynicotinic acid. Designed to target central nervous system excitatory pathways, Nooglutyl represents an advanced acyl-glutamate derivative capable of modulating glutamatergic receptor activity without inducing excitotoxic overstimulation.
By enhancing post-synaptic responsiveness across AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) receptor complexes, Nooglutyl facilitates hippocampal Long-Term Potentiation (LTP). Additionally, its 5-hydroxynicotinoyl moiety provides intrinsic antioxidant activity, neutralizing reactive oxygen species (ROS) and protecting neural cell cultures against hypoxic and ischemic injury.
Batch-verified for high analytical purity at Modern Aminos, Nooglutyl is offered in a pre-measured 10mg dry-fill solid oral capsule format (60 units per bottle). Researchers evaluating memory consolidation, glutamatergic neurotransmission, and anti-hypoxic cellular defense utilize Nooglutyl alongside complementary neuro-active reference standards available on the site, such as Bromantane, 9-Me-BC, NSI-189 Phosphate, and Semax.
| Compound Name | Nooglutyl (ONK-10) |
|---|---|
| Quantity / Formats Offered | 10mg Dry-Fill Capsules (60 Units per Bottle) |
| Chemical Structure | N-Acyl Glutamic Acid Derivative |
| Synonyms / Alt Names | N-(5-hydroxynicotinoyl)-L-glutamic acid, ONK-10, Nooglutil |
| CAS Number | 112193-35-8 |
| Chemical Formula | C11H12N2O6 |
| Molecular Weight | 268.22 g/mol |
| IUPAC Name | (2S)-2-[(5-hydroxypyridine-3-carbonyl)amino]pentanedioic acid |
| InChIKey | Protected Small Molecule Structure |
| SMILES Code | C1=C(C=NC=C1O)C(=O)NC(CCC(=O)O)C(=O)O |
The biochemical pathways and cellular targets include:
When evaluating research efficacy and published scientific literature:
To evaluate central glutamatergic signaling, neuroprotective pathways, and memory consolidation, researchers compare Nooglutyl against alternative reference standards available at Modern Aminos:
| Compound / Reference | Chemical Structure & Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| Nooglutyl | N-(5-hydroxynicotinoyl)-L-glutamic acid | Positively modulates AMPA/NMDA receptors, facilitates LTP, and provides anti-hypoxic cell protection | Focuses on glutamatergic synaptic plasticity, memory consolidation, hippocampal LTP, and ischemic neuroprotection |
| Bromantane | Synthetic Adamantane Actoprotector | Upregulates Tyrosine Hydroxylase (TH) gene expression to increase de novo dopamine synthesis while modulating GABA | Focuses on non-depleting dopaminergic biosynthesis, actoprotective physical endurance, and non-sedating anxiolysis |
| 9-Me-BC | Methylated β-Carboline Derivative | Induces Tyrosine Hydroxylase expression, drives dopaminergic neurite outgrowth, and supports Complex I | Focuses on structural dopaminergic neuron restoration, neurite arborization, and mitochondrial respiratory support |
| NSI-189 Phosphate | Benzylpiperazine Aminopyridine Complex | Stimulates neurogenesis and synaptic expansion specifically in the hippocampal dentate gyrus subgranular zone | Focuses on structural hippocampal volume recovery, dendritic arborization, and neural progenitor cell proliferation |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference nootropics. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct molecular weight (268.22 g/mol), exact amide structure fidelity, and complete absence of heavy metals or synthesis impurities.
Nooglutyl (N-(5-hydroxynicotinoyl)-L-glutamic acid) is a synthetic nootropic derivative combining glutamic acid with 5-hydroxynicotinic acid. It is classified as an acyl-glutamate derivative and glutamatergic receptor modulator.
Nooglutyl acts as a positive modulator of AMPA and NMDA glutamatergic receptors. It enhances post-synaptic responsiveness to endogenous glutamate, driving calcium influx and signaling cascades necessary for Long-Term Potentiation (LTP) in hippocampal cell cultures.
In oxygen-deprived cell models, Nooglutyl prevents mitochondrial membrane depolarization, preserves intracellular ATP pools, and quenches hydroxyl free radicals via its 5-hydroxynicotinoyl moiety, halting lipid peroxidation.
Modern Aminos provides Nooglutyl in pre-measured 10mg dry-fill solid oral capsules packaged in a 60 unit bottle to ensure solid-state stability and precise unit-mass control during benchtop weighing and assay dosing.
Nooglutyl focuses on central glutamatergic AMPA/NMDA receptor modulation, hippocampal LTP facilitation, and anti-hypoxic neuroprotection. Bromantane functions as an actoprotector that upregulates Tyrosine Hydroxylase gene transcription to increase dopaminergic biosynthesis while modulating GABA.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (268.22 g/mol) and structural identity prior to batch release.
Nooglutyl capsule bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, light exposure, and heat. Under controlled room temperature conditions, Nooglutyl maintains complete chemical stability throughout its designated shelf life.
DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
Capsule products are not intended for time-release and are for transport only.
DISCLAIMER: All compounds and research materials supplied by Modern Aminos are intended exclusively for in vitro laboratory research by qualified professionals. They are not medicinal products and have not been authorised by the European Medicines Agency or any national competent authority for human or veterinary use. They are not foods, food supplements, cosmetics or medical devices. Products must not be administered to humans or animals by any route and must not be used for in vivo experimentation or any other non-laboratory purpose. We will refuse or cancel orders, and may close accounts, where there is any indication of human or animal use. By purchasing, you confirm that products will be used only in a controlled laboratory environment by appropriately qualified personnel, in line with all applicable laws.
All products are sold in powder (lyophilized) form and require reconstitution with a suitable diluent for research purposes only. Research supplies (e.g., syringes, bacteriostatic water) are not included. No dosing instructions are provided. We adhere to all local and state laws around Research Only Chemical sales. We are not a pharmacy, nor do we promote or provide any advice for human or animal consumption. Please review our terms and conditions carefully before making a purchase on our website.
You must be 21+ and a licensed research professional
By clicking ”I Agree” you confirm that you have read and accepted the Terms and Conditions stated above
