What is Melatonin Based Amino Blend (20ML)?

Melatonin Based Amino Blend (20ML) is a six-component research solution of γ-aminobutyric acid (GABA), L-histidine hydrochloride, L-theanine, magnesium sulfate (Epsom salt), taurine and melatonin. Melatonin is the smallest component by mass at 0.2 mg/mL (200 mcg/mL); GABA, L-histidine HCl, magnesium sulfate and taurine are each present at 75 mg/mL.

Melatonin is the endogenous ligand of the G protein–coupled MT₁ and MT₂ receptors (Dubocovich et al., 2010), and GABA is the endogenous agonist of GABA-A chloride channels (Ghit et al., 2021). L-histidine contributes imidazole buffering chemistry (Brosnan & Brosnan, 2020), and taurine is an amino sulfonic acid (Ripps & Shen, 2012).

Batch-verified at Modern Aminos, it is supplied in one laboratory format, a 20 mL vial. The carrier is a water-based solution with benzyl alcohol (1%) as the preservative. Per-mL composition:

• Gamma-Aminobutyric Acid (GABA): 75 mg/mL
• L-Histidine HCl: 75 mg/mL
• L-Theanine: 50 mg/mL
• Magnesium Sulfate (Epsom Salt): 75 mg/mL
• Taurine: 75 mg/mL
• Melatonin: 0.2 mg/mL (200 mcg/mL)

Laboratories building metabolic panels often place it next to public reference listings such as GC-1 (Sobetirome).

Chemical and Molecular Data for Melatonin Based Amino Blend (20ML)

Each component is identified below from its PubChem record; amounts are per mL of finished solution, and salt forms are listed as weighed.

Gamma-Aminobutyric Acid (GABA) (75 mg/mL)

L-Histidine HCl (75 mg/mL)

L-Theanine (50 mg/mL)

Magnesium Sulfate (Epsom Salt) (75 mg/mL)

Taurine (75 mg/mL)

Melatonin (0.2 mg/mL)

What are the Mechanisms of Action?

The pathway chemistry behind Melatonin Based Amino Blend (20ML) in laboratory research includes:

• Melatonin receptors: Melatonin (N-acetyl-5-methoxytryptamine) is the endogenous ligand of the G protein–coupled MT₁ and MT₂ receptors (Dubocovich et al., 2010).
• GABA receptors: γ-Aminobutyric acid is the endogenous agonist of GABA-A receptors, pentameric ligand-gated chloride channels (Ghit et al., 2021).
• Imidazole chemistry: L-histidine’s imidazole side chain has a pKa near physiological pH, giving it buffering capacity; histidine is the precursor of histamine and, with β-alanine, of carnosine (Brosnan & Brosnan, 2020).
• Glutamine analog: L-theanine is N⁵-ethyl-L-glutamine (ChEBI:17394), an ethylamide of L-glutamic acid’s side-chain carboxyl and a structural analog of L-glutamine.
• Taurine chemistry: Taurine (2-aminoethanesulfonic acid) carries a sulfonic acid group instead of a carboxyl group; it is not incorporated into proteins and is conjugated to bile acids (Ripps & Shen, 2012).
• Magnesium salt: The magnesium source is magnesium sulfate heptahydrate (Epsom salt, CID 24843), which dissociates in water to Mg²⁺ and sulfate; the 75 mg/mL figure refers to the salt as weighed.

What Does Published Research Show for Melatonin Blend?

Published reviews on the components of Melatonin Based Amino Blend (20ML) center on their pathway biochemistry:

• Melatonin Receptor Nomenclature (IUPHAR, PMC): Dubocovich and colleagues set out the classification and pharmacology of the MT1 and MT2 G protein–coupled receptors (Dubocovich et al., 2010).
• GABA-A Receptor Structure (Review, PMC): Ghit and colleagues reviewed the subunit structure and pharmacology of GABA-A receptors (Ghit et al., 2021).
• Histidine Metabolism (Review, PMC): Brosnan and Brosnan reviewed histidine’s imidazole chemistry and its conversion to histamine, carnosine and urocanate (Brosnan & Brosnan, 2020).
• Taurine Biochemistry (Review, PMC): Ripps and Shen reviewed taurine’s synthesis, transport and roles as a free amino sulfonic acid (Ripps & Shen, 2012).
• Chemical Directory & Structure Verification (PubChem): GABA CID 119; L-Histidine CID 6274; L-Theanine CID 439378; Magnesium sulfate CID 24843; Taurine CID 1123; Melatonin CID 896. Identifiers on this page were checked against these records on October 8, 2026.
• Analytical Quality: Why chromatographic testing matters for reference materials is covered in Modern Aminos’ note on HPLC testing.

How does Melatonin Blend compare to other compounds?

To place Melatonin Blend among related research materials, the table compares it with other solutions and references available at Modern Aminos:

Frequently Asked Questions (FAQs)