5% RU-58841 (Stratum Corneum Research) (PSK-3841) is a synthetic non-steroidal antiandrogen (NSAA) engineered as a high-affinity competitive antagonist of the androgen receptor (AR). By occupying the ligand-binding domain of cellular androgen receptors, RU-58841 blocks endogenous dihydrotestosterone (DHT) and testosterone binding, preventing receptor nuclear translocation and downstream gene transcription in dermal papilla and follicular cell lines.
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5% RU-58841 (Stratum Corneum Research) (known chemically as PSK-3841, HMR-3841, or 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile) is a pioneer non-steroidal antiandrogen (NSAA). Developed specifically as a localized, high-affinity antagonist of the androgen receptor (AR), RU-58841 exhibits high binding selectivity for AR complexes over other steroid hormone receptors (such as glucocorticoid, estrogen, or progesterone receptors).
Unlike 5α-reductase inhibitors that block the enzymatic conversion of testosterone to dihydrotestosterone (DHT), RU-58841 acts directly at the receptor level. Occupying the ligand-binding domain (LBD) of target cell androgen receptors prevents both DHT and testosterone from forming active transcription complexes, insulating cellular machinery from androgenic signaling without altering systemic 5α-reductase enzyme levels.
Batch-verified for high analytical purity at Modern Aminos, 5% RU-58841 is offered as a standardized reference material for cell culture and biochemical research. Researchers evaluating dermal papilla cell proliferation, sebocyte lipogenesis, and androgen receptor dimerization kinetics utilize RU-58841 alongside complementary tissue-regulatory reference standards available on the site.
| Compound Name | RU-58841 (PSK-3841 / HMR-3841) |
|---|---|
| Quantity / Formats Offered | 5% RU-58841 in 30mL Amber Bottle with precision 1mL Dropper |
| Chemical Structure | Fluorinated Imidazolidinedione Non-Steroidal Antiandrogen |
| Synonyms / Alt Names | RU58841, PSK-3841, HMR-3841, RU-58841 Base, NSAA RU-58841 |
| CAS Number | 154992-24-2 |
| Chemical Formula | C17H18F3N3O3 |
| Molecular Weight | 369.34 g/mol |
| IUPAC Name | 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| InChIKey | OQVIYIHKXNWXKS-UHFFFAOYSA-N |
| SMILES Code | CC1(C(=O)N(C(=O)N1CCCCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C |
| Inert Contents | Propylene Glycol, Ethanol |
The biochemical pathways and cellular targets of RU-58841 in laboratory research include:
When evaluating research efficacy and published scientific literature for 5% RU-58841 (PSK-3841):
To evaluate receptor binding affinity, target specificity, and signaling mechanics, researchers compare 5% RU-58841 against alternative reference standards available at Modern Aminos:
In androgen signaling and cellular pathology research, the site of pathway intervention determines experimental parameters:
| Compound / Reference | Chemical Structure & Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| RU-58841 | Fluorinated Imidazolidinedione NSAA | Competitive AR antagonist; occupies ligand-binding domain to block DHT and testosterone binding | Focuses on androgen receptor isolation, dermal papilla cell protection, AR dimerization inhibition, and NSAA kinetics |
| Pyrilutamide (KX-826) | Second-Generation Non-Steroidal Antiandrogen | High-affinity competitive AR antagonist engineered for elevated local binding potency and rapid metabolic clearance | Focuses on next-generation AR competitive kinetics, local receptor occupancy, and sebocyte pathway modulation |
| CB-03-01 (Clascoterone) | Steroidal Antiandrogen (Cortexolone Derivative) | Competes with DHT for androgen receptor binding at the local tissue level, metabolizing into inactive cortexolone | Focuses on steroidal AR competition, local tissue antiandrogenic action, and sebaceous gland signaling assays |
| GHK-Cu | Copper-Chelated Tripeptide (Gly-His-Lys) | Upregulates collagen, elastin, and extracellular matrix (ECM) gene networks while stimulating SOD1 antioxidant activity | Focuses on tissue remodeling, extracellular matrix synthesis, angiogenesis, and anti-inflammatory signaling |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference compounds. Every batch of RU-58841 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct molecular weight (369.34 g/mol), exact antiandrogenic structure fidelity, and complete absence of heavy metals or synthesis impurities.
RU-58841 (PSK-3841) is a synthetic fluorinated imidazolidinedione derivative. It is classified chemically as a non-steroidal antiandrogen (NSAA) and competitive androgen receptor antagonist.
RU-58841 binds competitively to the ligand-binding domain (LBD) of human androgen receptors with nanomolar affinity (Ki ≈ 1.1 nM). By occupying the receptor site, it prevents endogenous DHT and testosterone from binding and initiating receptor dimerization.
Finasteride inhibits the 5α-reductase enzyme to block the conversion of testosterone into DHT. RU-58841 acts directly at the androgen receptor level, blocking both DHT and testosterone from binding to the receptor without altering enzyme activity or hormone synthesis.
In dermal papilla cell cultures, RU-58841 attenuates DHT-induced apoptosis and growth arrest, allowing researchers to study androgen-independent cellular proliferation, protein synthesis, and hair follicle growth dynamics in vitro.
RU-58841, Pyrilutamide (KX-826), and CB-03-01 all function as competitive androgen receptor antagonists. RU-58841 is the classic non-steroidal NSAA reference standard, Pyrilutamide is a high-affinity second-generation NSAA, and CB-03-01 is a steroidal cortexolone-derived antagonist.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (369.34 g/mol) and structural identity prior to batch release.
Reference material should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct heat, light exposure, and atmospheric moisture to maintain solid-state chemical stability.
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